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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">PHASES-Score</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p>Der <b>PHASES-Score</b> ist ein <a href="Scoring_(Medizin)" title="Scoring (Medizin)">Scoring</a>-System, mit dem das <a href="Zerebrales_Aneurysma#Rupturrisiko" title="Zerebrales Aneurysma">Rupturrisiko</a> eines <a href="Zerebrales_Aneurysma" title="Zerebrales Aneurysma">intrakraniellen Aneurysmas</a>, einer Aussackung der Hirnarterien, über einen Zeitraum von fünf Jahren abgeschätzt werden kann. <i>PHASES</i> ist ein <a href="Akronym" title="Akronym">Akronym</a> der verwendeten Variablen: <b>P</b> = Population, <b>H</b> = Hypertension (<a href="Bluthochdruck" class="mw-redirect" title="Bluthochdruck">Bluthochdruck</a>), <b>A</b> = Age (Alter), <b>S</b> = Size (Größe), <b>E</b> = earlier SAH from another aneurysm (frühere <a href="Subarachnoidalblutung" title="Subarachnoidalblutung">Subarachnoidalblutung</a> infolge eines anderen Aneurysmas), <b>S</b> = Site (Ort des Aneurysmas).
</p>
<table class="wikitable" style="width: 60%;">
<caption>PHASES-Score
</caption>
<tbody><tr>
<th>Variable</th>
<th>Kategorie</th>
<th>Punkte
</th></tr>
<tr>
<td rowspan="3">Population
</td>
<td>Nordamerikanisch, Europäisch (außer Finnisch)</td>
<td>0
</td></tr>
<tr>
<td>Japanisch</td>
<td>3
</td></tr>
<tr>
<td>Finnisch</td>
<td>5
</td></tr>
<tr>
<td rowspan="2"><a href="Bluthochdruck" class="mw-redirect" title="Bluthochdruck">Bluthochdruck</a>
</td>
<td>Nein</td>
<td>0
</td></tr>
<tr>
<td>Ja</td>
<td>1
</td></tr>
<tr>
<td rowspan="2">Alter der Person
</td>
<td>< 70 Jahre</td>
<td>0
</td></tr>
<tr>
<td>≥ 70 Jahre</td>
<td>1
</td></tr>
<tr>
<td rowspan="4">Größe des Aneurysmas
</td>
<td>< 7,0 mm</td>
<td>0
</td></tr>
<tr>
<td>7,0–9,9 mm</td>
<td>3
</td></tr>
<tr>
<td>10,0–19,9 mm</td>
<td>6
</td></tr>
<tr>
<td>≥ 20,0 mm</td>
<td>10
</td></tr>
<tr>
<td rowspan="2">Frühere Subarachnoidalblutung durch ein anderes Aneurysma
</td>
<td>Nein</td>
<td>0
</td></tr>
<tr>
<td>Ja</td>
<td>1
</td></tr>
<tr>
<td rowspan="3">Ort des Aneurysmas
</td>
<td><a href="Arteria_carotis_interna" title="Arteria carotis interna">Arteria carotis interna</a></td>
<td>0
</td></tr>
<tr>
<td><a href="Arteria_cerebri_media" title="Arteria cerebri media">Arteria cerebri media</a></td>
<td>2
</td></tr>
<tr>
<td><a href="Arteria_cerebri_anterior" title="Arteria cerebri anterior">Arteria cerebri anterior</a>, <a href="Arteria_communicans_posterior" title="Arteria communicans posterior">Arteria communicans posterior</a>, Arterien der hinteren Zirkulation (<a href="Arteria_cerebri_posterior" title="Arteria cerebri posterior">Arteria cerebri posterior</a>, <a href="Arteria_vertebralis" title="Arteria vertebralis">Arteria vertebralis</a>, <a href="Arteria_basilaris" title="Arteria basilaris">Arteria basilaris</a>, Kleinhirnarterien)</td>
<td>4
</td></tr></tbody></table>
<table class="wikitable">
<caption>Auswertung
</caption>
<tbody><tr>
<th>PHASES-Score</th>
<th>5-Jahres-Risiko einer Aneurysmaruptur
</th></tr>
<tr>
<td>≤ 2</td>
<td>0,4 %
</td></tr>
<tr>
<td>3</td>
<td>0,7 %
</td></tr>
<tr>
<td>4</td>
<td>0,9 %
</td></tr>
<tr>
<td>5</td>
<td>1,3 %
</td></tr>
<tr>
<td>6</td>
<td>1,7 %
</td></tr>
<tr>
<td>7</td>
<td>2,4 %
</td></tr>
<tr>
<td>8</td>
<td>3,2 %
</td></tr>
<tr>
<td>9</td>
<td>4,3 %
</td></tr>
<tr>
<td>10</td>
<td>5,3 %
</td></tr>
<tr>
<td>11</td>
<td>7,2 %
</td></tr>
<tr>
<td>≥ 12</td>
<td>17,8 %
</td></tr></tbody></table>
<div class="mw-heading mw-heading2"><h2 id="Geschichte">Geschichte</h2></div>
<p>Der PHASES-Score wurde 2013 veröffentlicht und beruht auf sechs <a href="Prospektive_Studie" title="Prospektive Studie">prospektiven Studien</a> mit 8382 Teilnehmern.<sup id="cite_ref-greving2013_1-0" class="reference"><a href="#cite_note-greving2013-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Ein höherer PHASES-Score ist mit einem erhöhten Risiko für die Größenzunahme eines Aneurysmas assoziiert.<sup id="cite_ref-backes2015_2-0" class="reference"><a href="#cite_note-backes2015-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Die Form des Aneurysmas, die mit einem erhöhten Rupturrisiko assoziiert sein kann, ging nicht in den Score ein.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-greving2013-1"><span class="mw-cite-backlink"><a href="#cite_ref-greving2013_1-0">↑</a></span> <span class="reference-text">Jacoba P. Greving et al.: <cite style="font-style:italic">Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies</cite>. In: <cite style="font-style:italic">The Lancet Neurology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>13</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 2013, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>59–66</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/s1474-4422%2813%2970263-1">10.1016/s1474-4422(13)70263-1</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/24290159?dopt=Abstract">PMID 24290159</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:PHASES-Score&rft.atitle=Development+of+the+PHASES+score+for+prediction+of+risk+of+rupture+of+intracranial+aneurysms%3A+a+pooled+analysis+of+six+prospective+cohort+studies&rft.au=Jacoba+P.+Greving+et+al.&rft.date=2013&rft.doi=10.1016%2Fs1474-4422%2813%2970263-1&rft.genre=journal&rft.issue=1&rft.jtitle=The+Lancet+Neurology&rft.pages=59-66&rft.pmid=24290159&rft.volume=13" style="display:none"> </span></span>
</li>
<li id="cite_note-backes2015-2"><span class="mw-cite-backlink"><a href="#cite_ref-backes2015_2-0">↑</a></span> <span class="reference-text">Daan Backes et al.: <cite style="font-style:italic">PHASES Score for Prediction of Intracranial Aneurysm Growth</cite>. In: <cite style="font-style:italic">Stroke</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>46</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5</span>, 2015, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1221–1226</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1161/strokeaha.114.008198">10.1161/strokeaha.114.008198</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/25757900?dopt=Abstract">PMID 25757900</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:PHASES-Score&rft.atitle=PHASES+Score+for+Prediction+of+Intracranial+Aneurysm+Growth&rft.au=Daan+Backes+et+al.&rft.date=2015&rft.doi=10.1161%2Fstrokeaha.114.008198&rft.genre=journal&rft.issue=5&rft.jtitle=Stroke&rft.pages=1221-1226&rft.pmid=25757900&rft.volume=46" style="display:none"> </span></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">Nima Etminan, Gabriël J.E. Rinkel: <cite style="font-style:italic">Unruptured intracranial aneurysms: development, rupture and preventive management</cite>. In: <cite style="font-style:italic">Nature Reviews Neurology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>12</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>12</span>, 2016, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>699–713</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/nrneurol.2016.150">10.1038/nrneurol.2016.150</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/28145447?dopt=Abstract">PMID 28145447</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:PHASES-Score&rft.atitle=Unruptured+intracranial+aneurysms%3A+development%2C+rupture+and+preventive+management&rft.au=Nima+Etminan%2C+Gabri%C3%ABl+J.E.+Rinkel&rft.date=2016&rft.doi=10.1038%2Fnrneurol.2016.150&rft.genre=journal&rft.issue=12&rft.jtitle=Nature+Reviews+Neurology&rft.pages=699-713&rft.pmid=28145447&rft.volume=12" style="display:none"> </span></span>
</li>
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